Current Therapy of Chronic Myelogenous Leukemia.
نویسندگان
چکیده
منابع مشابه
imatinib therapy in chronic myelogenous leukemia and thyroid function tests.
introduction: imatinib, a tyrosine kinase inhibitor which resulted in much improvement in the treatment of chronic myelogenous leukemia (cml), may adversely affect thyroid gland function. to date, assessment of thyroid function during imatinib therapy has limited to retrospective studies. the aim of this study was to evaluate the effects of imatinib on thyroid function in a prospective manner. ...
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Chronic myelogenous leukemia (CML) is a clonal proliferative disease originating from a pluripotential stem cell in which a 9:22 translocation, Philadelphia (Ph) chromosome, results in the production of BCR-ABL fusion protein that has constitutive tyrosine kinase activity and deregulates signal transduction pathways, thus causing leukemia. The natural course of CML is usually triphasic (chronic...
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In chronic myelogenous leukemia (CML), the mature granulocytes originate from a stem cell line harboring an abnormal chromosome, therefore it is possible that metabolic-functional abnormalities occur in the morphologically mature cells. In the present study, the phagocytic activity including intracellular killing, nitro blue tetrazolium (NBT) reduction, and phagocytosis were studied in 37 CML p...
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even clinical relapses sometimes occurring as late as 5 to 10 T years after transplantation is being recognized in recipients HE TERM CHRONIC myelogenous leukemia (CML) belies the insidious, unsparing course of this lethal of either T-lymphocyte–depleted or unmanipulated grafts. hematopoietic malignancy. In CML, the malignant transforInterferon-a (IFN-a) therapy for CML. Therapy of mation of a ...
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VER THE PAST few years, several important studies 0 related to the treatment of Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia (CML) have matured. These include single and multi-institutional programs with allogeneic bone marrow transplantation (BMT), interferon-a (IFN-A), autologous stem cell transplantation, and other investigational agents or modalities. As in other field...
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ژورنال
عنوان ژورنال: Internal Medicine
سال: 2002
ISSN: 0918-2918,1349-7235
DOI: 10.2169/internalmedicine.41.254